Roche Cobas c 111 / c 311 Bi-Directional LIS Interfacing Guide
Complete engineering specification, HL7/ASTM protocols, pinouts, and parameter mapping for Roche Cobas c 111 / c 311 on AILS Cloud LIMS.
1. Roche Cobas c 111 / c 311 Interfacing Overview & Diagnostic Workflow
The Roche Cobas c 111 / c 311 is a high-performance clinical chemistry analyzer dedicated to routine photometric assays, enzymatic kinetics, and ion-selective electrode (ISE) electrolytes. Connecting the Roche Cobas c 111 / c 311 to AILS Cloud LIMS establishes a closed-loop analytical cycle—automating test profile assignment, monitoring serum index flags (Hemolysis, Icterus, Lipemia), and preventing reporting errors across high-volume chemistry workloads.
As sample tubes enter the Roche Cobas c 111 / c 311 reaction carousels, the onboard barcode reader queries AILS Gateway via HL7 v2.5 / ASTM E1394 to pull ordered test profiles (e.g. Liver Function, Renal Panel, Lipid Profile) in under 300ms.
AILS automatically reads HIL (Hemolysis, Icterus, Lipemia) interferent flags emitted by the Roche Cobas c 111 / c 311, warning technologists when sample integrity compromises photometric accuracy and logging auto-dilution rerun factors.
2. Roche Cobas c 111 / c 311 RS-232 Serial Port & Pinout Configuration
TCP/IP Ethernet or RS-232 DB9 Serial. Host Port: 6000. Baud: 19200 or 38400, Parity: None, Data Bits: 8, Stop: 1.
[Instrument DB9] [AILS Gateway PC] Pin 2 (TxD / Data Out) ---------> Pin 2 (RxD / Data In) Pin 3 (RxD / Data In) <--------- Pin 3 (TxD / Data Out) Pin 5 (GND / Signal) <========> Pin 5 (GND / Signal) Pin 7 (RTS) & Pin 8 (CTS) [Loopback or None] Baud: 19200 / 38400 | Data Bits: 8 | Parity: None | Stop: 1
3. Roche Cobas c 111 / c 311 HL7 v2.x Message Stream
Below is a validated communication frame transmitted between the Roche Cobas c 111 / c 311 and AILS LIS middleware:
MSH|^~\&|COBAS-C311|Roche|AILS_LIMS|LAB_MAIN|20260815130000||ORU^R01|MSG009890|P|2.5 PID|1||P982375||Johnson^Robert||19651130|M OBR|1|ORD982375|ACC2026081505|LIPID^Lipid Panel|||20260815125500 OBX|1|NM|CHOL2^Cholesterol Gen.2||215.0|mg/dL|140.0-200.0|H|||F OBX|2|NM|TRIGL^Triglycerides||165.0|mg/dL|50.0-150.0|H|||F OBX|3|NM|NA^Sodium ISE||140.5|mmol/L|136.0-145.0|N|||F
4. Roche Cobas c 111 / c 311 Clinical Parameter LOINC & Reference Range Dictionary
| Instrument Code | LOINC Code | Clinical Parameter Name | Standard Units | Default Reference Range |
|---|---|---|---|---|
| CHOL2 | 2093-3 | Total Cholesterol | mg/dL | 140.0 - 200.0 |
| TRIGL | 2571-8 | Triglycerides | mg/dL | 50.0 - 150.0 |
| NA | 2951-2 | Sodium ISE | mmol/L | 136.0 - 145.0 |
5. Roche Biomedical Engineering Field Notes & Gotchas
Cobas requires strict QRY^Q02 worklist handshake when operating in host-query mode.
Verify calibration curve lot numbers are registered before test run dispatch.
ISE channel test codes must match the specific Cobas channel numbering schema.
Frequently Asked Questions: Roche Cobas c 111 / c 311 LIS Interfacing
Common biomedical engineering questions regarding connection, worklist setup, and data capture with AILS Cloud LIMS.
Q: What interface protocol does Roche Cobas c311 use?
Roche Cobas c311 uses HL7 v2.5 or ASTM E1394 (Roche Host Interface protocol) over TCP/IP socket (Port 6000) or RS-232 serial.
Q: How does Cobas c311 communicate in Host-Query mode?
When a sample tube is placed on the carousel, the barcode reader queries AILS LIMS and receives test order profiles.
Q: How are STAT urgent samples prioritized on Cobas c311?
When a STAT order is sent from AILS LIMS with priority code S in the order segment, Cobas processes it immediately.
Q: How are serum indices (Lipemia, Hemolysis, Icterus) captured?
Serum indices transmitted in comment or result records are mapped to specimen integrity warnings in AILS LIMS.
Q: What baud rate is used for Cobas c111 serial interfacing?
Standard baud rate is 19200 or 38400 bps, 8 data bits, Parity None, 1 stop bit.
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Connect Your Roche Cobas c 111 / c 311 to AILS in Under 15 Minutes
Our specialized biomedical engineering team provides complete plug-and-play drivers, cable diagrams, and bi-directional test verification for the Roche Cobas c 111 / c 311.