Roche Cobas c 111 / c 311 Bi-Directional LIS Interfacing Guide
Complete engineering specification, HL7/ASTM protocols, pinouts, and parameter mapping for Roche Cobas c 111 / c 311 on AILS Cloud LIMS.
1. Instrument Overview & Interfacing Architecture
The Roche Cobas c 111 / c 311 is a high-performance biochemistry instrument designed for diagnostic laboratories and hospital health networks. Integrating this analyzer directly with AILS Cloud LIMS eliminates manual transcription delays, prevents typographical patient identification errors, and automatically enforces Westgard delta check algorithms.
AILS automatically generates worklist queries (QRY^Q02 / ASTM orders) mapped to patient accession barcodes and pushes test instructions directly to the instrument sample tray.
Raw OBX / Result records are parsed instantly within 200 milliseconds, flagged for abnormal reference ranges, and linked to pathologist digital signature queues.
2. Hardware Connection & Communication Settings
3. Sample Message Wire Frame
Below is a real-world communication frame transmitted between the Roche Cobas c 111 / c 311 and AILS LIS middleware:
MSH|^~\&|COBAS-C311|Roche|AILS_LIMS|LAB_MAIN|20260815130000||ORU^R01|MSG009890|P|2.5 PID|1||P982375||Johnson^Robert||19651130|M OBR|1|ORD982375|ACC2026081505|LIPID^Lipid Panel|||20260815125500 OBX|1|NM|CHOL2^Cholesterol Gen.2||215.0|mg/dL|140.0-200.0|H|||F OBX|2|NM|TRIGL^Triglycerides||165.0|mg/dL|50.0-150.0|H|||F OBX|3|NM|NA^Sodium ISE||140.5|mmol/L|136.0-145.0|N|||F
4. Parameter & LOINC Standard Code Mapping
| Instrument Code | LOINC Code | Clinical Parameter Name | Standard Units | Default Reference Range |
|---|---|---|---|---|
| CHOL2 | 2093-3 | Total Cholesterol | mg/dL | 140.0 - 200.0 |
| TRIGL | 2571-8 | Triglycerides | mg/dL | 50.0 - 150.0 |
| NA | 2951-2 | Sodium ISE | mmol/L | 136.0 - 145.0 |
5. Biomedical Engineering Tips & Common Gotchas
Cobas requires strict QRY^Q02 worklist handshake when operating in host-query mode.
Verify calibration curve lot numbers are registered before test run dispatch.
ISE channel test codes must match the specific Cobas channel numbering schema.
Frequently Asked Questions: Roche Cobas c 111 / c 311 Interfacing
Common biomedical engineering questions regarding connection, worklist setup, and data capture with AILS Cloud LIMS.
Q: What interface protocol does Roche Cobas c311 use?
Roche Cobas c311 uses HL7 v2.5 or ASTM E1394 (Roche Host Interface protocol) over TCP/IP socket (Port 6000) or RS-232 serial.
Q: How does Cobas c311 communicate in Host-Query mode?
When a sample tube is placed on the carousel, the barcode reader queries AILS LIMS and receives test order profiles.
Q: How are STAT urgent samples prioritized on Cobas c311?
When a STAT order is sent from AILS LIMS with priority code S in the order segment, Cobas processes it immediately.
Q: How are serum indices (Lipemia, Hemolysis, Icterus) captured?
Serum indices transmitted in comment or result records are mapped to specimen integrity warnings in AILS LIMS.
Q: What baud rate is used for Cobas c111 serial interfacing?
Standard baud rate is 19200 or 38400 bps, 8 data bits, Parity None, 1 stop bit.
Connect Your Roche Cobas c 111 / c 311 to AILS in Under 15 Minutes
Our specialized biomedical engineering team provides complete plug-and-play drivers, cable diagrams, and bi-directional test verification for the Roche Cobas c 111 / c 311.